{output_format}: Get properties by SMILES notation

API: nih.gov:pubchem-property-api
Endpoint: /smiles/{smiles}/property/{properties}/{output_format}
Response format: unknown
Auth: unknown
Method: GET
Last Status: 200
Latency: 836ms

Description

Retrieve chemical properties using the Simplified Molecular Input Line Entry System (SMILES) notation.

Parameters (3)

output_format (string, path, required)

Response format

Constraints: {'enum': ['JSON', 'XML']}

properties (string, path, required)

Comma-separated list of property names to retrieve

smiles (string, path, required)

SMILES notation representing the molecular structure (e.g., 'CCO' for ethanol, 'CC(=O)Oc1ccccc1C(=O)O' for aspirin).

Examples (1)

Get properties by SMILES notation openapi-spec

curl 'https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/smiles/CCO/property/MolecularWeight/JSON'

import requests

resp = requests.get("https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/smiles/CCO/property/MolecularWeight/JSON")
data = resp.json()

import zingu_apis

api = zingu_apis.api("pubchem-property")
result = api.fetch("smiles/{smiles}/property/{properties}/{output_format}")

for item in result:
    print(item)

const resp = await fetch("https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/smiles/CCO/property/MolecularWeight/JSON");
const data = await resp.json();

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Probe History

Latency

Status Codes

Time	Status	Latency
2026-04-16 01:11:38.411237	200	836ms
2026-04-15 01:49:02.253725	200	794ms
2026-04-14 02:30:36.497293	200	806ms
2026-04-12 14:43:28.286090	200	777ms
2026-04-10 02:20:21.941825	200	705ms
2026-04-09 03:38:46.641365	200	757ms