{output}: Search compounds by SMILES

API: nih.gov:pubchem-api
Endpoint: /pug/compound/smiles/{smiles}/cids/{output}
Response format: unknown
Auth: unknown
Method: GET
Last Status: 200
Latency: 751ms

Description

Retrieve CIDs for compounds matching the given SMILES (Simplified Molecular Input Line Entry System) string.

Parameters (2)

output (string, path, required)

Output format

Constraints: {'enum': ['JSON', 'XML']}

smiles (string, path, required)

SMILES representation of the chemical structure

Examples (1)

Search compounds by SMILES openapi-spec

curl 'https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/smiles/CC(=O)Oc1ccccc1C(=O)O/cids/JSON'

import requests

resp = requests.get("https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/smiles/CC(=O)Oc1ccccc1C(=O)O/cids/JSON")
data = resp.json()

import zingu_apis

api = zingu_apis.api("pubchem")
result = api.fetch("pug/compound/smiles/{smiles}/cids/{output}")

for item in result:
    print(item)

const resp = await fetch("https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/smiles/CC(=O)Oc1ccccc1C(=O)O/cids/JSON");
const data = await resp.json();

Truncate

Auto Table Raw

Probe History

Latency

Status Codes

Time	Status	Latency
2026-04-16 00:39:49.701483	200	751ms
2026-04-15 00:28:20.245683	200	650ms
2026-04-14 03:41:54.758054	200	862ms
2026-04-12 15:27:15.764304	200	657ms
2026-04-10 06:50:53.640251	200	564ms
2026-04-09 01:01:54.543938	200	858ms