GET /substructure/{smiles}
Summary: Substructure search
Operation ID: substructureSearch
Auth: unknown
Operation ID: substructureSearch
Auth: unknown
Description
Search for molecules containing a given substructure specified by SMILES.
Parameters (1)
smiles
(string, path, required)
SMILES string of the substructure to search for
Examples (4)
| Title | Type | URL | Action |
|---|---|---|---|
| Benzene ring substructure search | curl |
https://www.ebi.ac.uk/chembl/api/data/substructure/c1ccccc1 |
|
| Carboxylic acid group substructure search | curl |
https://www.ebi.ac.uk/chembl/api/data/substructure/C(=O)O |
|
| Phenylalanine-like substructure search | curl |
https://www.ebi.ac.uk/chembl/api/data/substructure/NC(Cc1ccccc1)C(=O)O |
|
| Substructure search by SMILES | doc_extracted |
https://www.ebi.ac.uk/chembl/api/data/substructure/CC(=O)CC(C1=C(O)c2ccccc2OC1=O)c3ccccc3 |
Probe History
Status Codes
| Time | Status | Latency | Size |
|---|---|---|---|
| 2026-03-23 09:50:52.692500 | 200 | 2636ms | |
| 2026-03-23 09:45:53.752228 | 200 | 3620ms | |
| 2026-03-23 09:36:44.160487 | 200 | 2665ms | |
| 2026-03-23 09:11:25.223032 | 200 | 428ms |
Response Changes
| When | Old | New |
|---|---|---|
| 2026-03-23 09:36:44.160487 | afc8933cc93b |
e7e53b37509c |
| 2026-03-23 09:45:53.752228 | e7e53b37509c |
b42c73830a98 |
| 2026-03-23 09:50:52.692500 | b42c73830a98 |
f8ae214f3e7f |