Ensembl REST API

The Ensembl REST API provides access to genomic data from Ensembl and Ensembl Genomes. It supports queries for genes, transcripts, proteins, variants, sequences, homology, and cross-references across hundreds of species.

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Base URL: https://rest.ensembl.org/
Auth: none
Endpoints: 23
Reachable: yes
CORS: unknown
Last checked: 2026-03-14 16:09:22.868257

Links

Homepage: https://www.ensembl.org/contact
API Base: https://rest.ensembl.org/
Documentation:

100.0%

Uptime (7d)

242ms

Avg latency (7d)

16

Probes (7d)

Latency (7d)

Success Rate (7d)

Topics

GENOMICS, SCIENCE

Endpoints

Method Path Summary Auth Last Status Latency
GET /archive/id/{id} Get archived identifier none — —
GET /genetree/id/{id} Get gene tree none — —
GET /homology/id/{species}/{id} Get homologous genes by ID none — —
GET /homology/symbol/{species}/{symbol} Get homologous genes — — —
GET /info/assembly/{species} Get assembly information none — —
GET /info/data Get data releases — 200 210ms
GET /info/ping Check service status none 200 155ms
GET /info/rest Get API version — 200 148ms
GET /info/species List all available species none 200 285ms
GET /lookup/id/{id} Find gene by Ensembl ID none 200 177ms
GET /lookup/symbol/{species}/{symbol} Find gene by symbol none 200 152ms
GET /ontology/ancestors/{id} Get ontology ancestors none — —
GET /ontology/descendants/{id} Get ontology descendants none — —
GET /overlap/id/{id} Get overlapping features none — —
GET /overlap/region/{species}/{region} Get overlapping features none 200 266ms
GET /phenotype/gene/{species}/{gene} Get gene phenotypes none — —
GET /sequence/id/{id} Get sequence by ID none 200 170ms
GET /sequence/region/{species}/{region} Get genomic sequence none — —
GET /taxonomy/classification/{id} Get taxonomic classification none — —
GET /taxonomy/name/{name} Search taxonomy by name — — —
GET /variation/{species}/{id} Get variant information none — —
GET /vep/{species}/id/{id} Variant Effect Predictor by ID none — —
GET /vep/{species}/region/{region}/{allele} Variant Effect Predictor by region none — —
GET /xrefs/id/{id} Get cross-references none — —
GET /xrefs/symbol/{species}/{symbol} Lookup external symbol none — —